Hemolitic action of Naja naja atra cardiotoxin on erythrocytes from different animals
نویسندگان
چکیده
منابع مشابه
Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin from Naja naja atra
Cardiotoxin (CTX) from Naja naja atra venom (NNAV) reportedly had analgesic effect in animal models but its role in inflammation and arthritis was unknown. In this study, we investigated the analgesic, anti-inflammatory, and antiarthritic actions of orally administered CTX-IV isolated from NNAV on rodent models of inflammation and adjuvant arthritis. CTX had significant anti-inflammatory effect...
متن کاملCharacterization of a Partially Structured Intermediate of Cardiotoxin VI from Naja naja atra at High Temperature
The unfolding kinetics of cardiotoxin analogue VI from Taiwan cobra (Naja naja atra) have been studied at 473 K, pH 7.0 in the presence of 0.1 M NaCl using molecular dynamics simulations for 50 ns. Trajectory structures stored at every 25 ps (2000 structures) were probed at molecular (RMSD and radius of gyration) and residue (RMSF, surface area accessibility and secondary structures) level reso...
متن کاملDetection of Naja atra Cardiotoxin Using Adenosine-Based Molecular Beacon
This study presents an adenosine (A)-based molecular beacon (MB) for selective detection of Naja atra cardiotoxin (CTX) that functions by utilizing the competitive binding between CTX and the poly(A) stem of MB to coralyne. The 5'- and 3'-end of MB were labeled with a reporter fluorophore and a non-fluorescent quencher, respectively. Coralyne induced formation of the stem-loop MB structure thro...
متن کاملDifferential Effects of Naja naja atra Venom on Immune Activity
Previous studies reported that Naja naja atra venom (NNAV) inhibited inflammation and adjuvant arthritis. Here we investigated the role of NNAV in regulation of immune responses in mice. Oral administration of NNAV to normal mice showed significant increase in natural killer cell activity, B lymphocyte proliferation stimulated by lipopolysaccharides, and antibody production in response to sheep...
متن کاملCardiotoxin III from the Taiwan cobra (Naja naja atra). Determination of structure in solution and comparison with short neurotoxins.
The structure in solution of cardiotoxin III, a membrane toxin purified from the venom of the Taiwan cobra, Naja naja atra, is reported. Sequence-specific assignment of 1H-NMR lines was completed and the NMR data show the presence of a triple and a double-stranded antiparallel beta-sheet. Many NOE cross peaks identified in NOESY spectra were applied as distance constraints based on a hybrid dis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Venomous Animals and Toxins including Tropical Diseases
سال: 2006
ISSN: 1678-9199
DOI: 10.1590/s1678-91992006000100004